**Overview**
MOTS c is a mitochondrial‑derived peptide consisting of 16 amino acids encoded by the mitochondrial 12S rRNA gene. Unlike most peptides encoded by nuclear DNA, MOTS‑c originates from mitochondrial DNA and helps regulate cellular metabolism and stress responses. Studies show that MOTS‑c translocates to the nucleus under metabolic stress where it promotes expression of genes linked to energy expenditure and antioxidant defence【595839346434819†L205-L215】. Exercise increases endogenous MOTS‑c levels, and administration of MOTS‑c in rodent models enhances physical performance, improves insulin sensitivity, and influences skeletal muscle metabolism and gene expression【595839346434819†L205-L215】. It remains an experimental peptide with no approved therapeutic uses【595839346434819†L217-L225】.

**Key Research Applications**
– *Mitochondrial signalling and metabolic regulation*: Study how MOTS‑c modulates mitochondrial function, oxidative metabolism and stress responses through AMPK pathways.
– *Insulin sensitivity and glucose homeostasis*: Explore MOTS‑c’s effects on insulin signalling and glucose utilisation in metabolic syndrome and Type 2 diabetes models.
– *Exercise physiology*: Investigate how endurance exercise stimulates MOTS‑c production and how exogenous MOTS‑c administration affects muscle performance and fatigue resistance【595839346434819†L205-L215】.
– *Ageing and sarcopenia*: Evaluate MOTS‑c’s ability to preserve muscle mass and function during ageing and its interaction with mitochondrial DNA regulation.
– *Cellular stress adaptation*: Examine MOTS‑c’s nuclear translocation and gene regulation under oxidative or metabolic stress.

**Quality & Handling**
– Provided as a lyophilised powder in high purity for laboratory research.
– Reconstitute with sterile water or appropriate buffer to prepare stock solution.
– Aliquot and store reconstituted MOTS‑c at −20 °C to prevent repeated freeze–thaw cycles.
– Use within 6 months of reconstitution for optimal activity.

**Important Notice**
This product is for research use only. It is not intended for human or veterinary use, medical or diagnostic applications. MOTS‑c is considered an experimental peptide with no approved medical indications【595839346434819†L217-L225】.

**Why Choose Anytime Compounds?**
Anytime Compounds supplies MOTS‑c manufactured under rigorous quality control to ensure high purity and integrity. Our peptides undergo third‑party testing and are shipped with certificates of analysis, giving you confidence in your research results.