**Overview**
NAD+ (nicotinamide adenine dinucleotide) is a ubiquitous coenzyme essential for redox reactions and energy metabolism. As an electron carrier in glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation, it cycles between oxidised NAD+ and reduced NADH, transferring electrons to support ATP synthesis. Beyond its role as a redox cofactor, NAD+ serves as a substrate for NAD+-dependent enzymes including sirtuins, poly(ADP‑ribose) polymerases (PARPs) and CD38, linking it to DNA repair, chromatin remodelling, cellular senescence and immune modulation【268194240673303†L168-L176】. Research interest in NAD+ has grown due to its involvement in ageing and metabolic diseases and its potential to regulate mitochondrial function.

**Key Research Applications**
– *Mitochondrial and energy metabolism*: Investigate NAD+’s role in glycolysis, oxidative phosphorylation and the electron transport chain, and how NAD+/NADH ratios influence cellular energy balance.
– *DNA repair and genome integrity*: Examine NAD+-dependent PARP activity and its function in DNA damage response and base excision repair【268194240673303†L168-L176】.
– *Epigenetics and sirtuin signalling*: Study the regulation of deacetylase enzymes (SIRT1–7) by NAD+ and their impact on gene expression, chromatin structure and longevity【268194240673303†L168-L176】.
– *Immunometabolism & inflammation*: Explore how NAD+ modulates immune cell function and inflammatory signalling through CD38/ADP‑ribosyl cyclase pathways.
– *Ageing and senescence*: Model declines in cellular NAD+ levels with age and investigate interventions to restore NAD+ to delay age-related functional decline.
– *Metabolic disorders*: Investigate NAD+ supplementation or depletion in models of metabolic disorders, neurodegeneration or cardiometabolic diseases.

**Quality & Handling**
– Supplied as a lyophilised or crystalline coenzyme in high purity (>98%) suitable for laboratory research.
– Reconstitute using sterile deionised water or buffer; filter sterilise if necessary.
– For maximum stability, aliquot reconstituted solution and store at −20 °C; avoid repeated freeze–thaw cycles.
– Use appropriate personal protective equipment and handle according to institutional laboratory practices.

**Important Notice**
This product is provided strictly for laboratory research use only. It is not intended for human or veterinary consumption, clinical applications, or household use. Any reference to biological activity is provided for educational research purposes.

**Why Choose Anytime Compounds?**
Anytime Compounds supplies NAD+ of exceptional purity that meets rigorous quality standards. Each lot undergoes thorough analytical testing and is accompanied by certificates of analysis for transparency. Our commitment to quality ensures consistent results and reliability in your research.