Overview

LL-37 is a 37-amino-acid cathelicidin antimicrobial peptide (AMP), the only human cathelicidin identified to date, derived from the C-terminal region of the CAMP gene. LL-37 forms an α-helical structure that disrupts bacterial membranes and viral envelopes, giving it broad antimicrobial activity, including anti-fungal effects. This peptide is cleaved from an inactive precursor by skin serine proteases and is produced by epithelial cells and infiltrating neutrophils. LL-37 also functions as an immunomodulatory “alarmin” peptide: it induces cytokine and chemokine release, recruits immune cells, and promotes endothelial cell proliferation and angiogenesis.

Key Research Applications

– Studying LL-37’s membrane-disrupting mechanisms and antimicrobial efficacy against bacteria, viruses, and fungi.
– Investigating its role in innate immunity, including chemotactic and cytokine-inducing activities.
– Exploring the alarmin functions of LL-37 in wound healing, angiogenesis, and inflammatory skin disease.
– Characterizing proteolytic processing and regulation of cathelicidin peptides by serine proteases.
– Developing LL-37 derivatives or analogues for potential therapeutic applications and understanding structure‑activity relationships.

Quality & Handling

– Provided as a lyophilized powder for reconstitution with sterile, bacteriostatic water (not included).
– For maximum stability, aliquot reconstituted solution and store at –20 °C; avoid repeated freeze–thaw cycles.
– Synthesized under stringent cGMP standards with purity and identity verified by analytical techniques.
– Not intended for clinical, veterinary, or agricultural use; for laboratory research only.

Important Notice

This product is for laboratory research purposes only and is not for human or animal consumption.

Why Choose Anytime Compounds?

Anytime Compounds supplies high-quality research peptides and blends with third-party testing, careful handling, and responsive customer support to ensure dependable results.